5-fluoruracil

Manejo clínico e intervenção farmacêutica de toxicidades no tratamento de câncer colorretal metastático

  • Autor:
  • Manejo clínico e intervenção farmacêutica de toxicidades no tratamento de câncer colorretal metastático
  • Palavras-chave:
  • 5-fluoruracil
  • câncer colorretal
  • capecitabina
  • CTCAE
  • irinotecano
  • metástase
  • toxicidade
Resumo: Introduction: Colorectal cancer is a neoplasm that affects the segments of the large intestine. Treatment is dependent on the size, location and extent of the tumor, as the metastatic colorectal cancer can spread to other organs consequently reducing the chances of cure. According to the World Health Organization, an adverse reaction to medications is defined as any harmful and unintended response that occurs due to the use of any medication in its usual dose. Toxicity encompasses the possible side effects of a treatment, which can cause delays in the chemotherapy cycle, reduction of the dose of drugs, hospital admissions, substitution and / or interruption of treatment, which can compromise the safety of the treatment, causing life-threatening. The work aims to present the toxicities related to the “very common” adverse reactions, most frequent of the drugs 5-fluorouracil, capecitabine and irinotecan and their respective management in metastatic colorectal cancer for intervention by the oncological pharmacist. Review: From the methodology, 30 articles were selected because they are in the full version and according to the theme. This is a literature review of national and international articles in databases (Scielo, Lilacs, ScienceDirect and Google Scholar). Discussion: Toxicities should be evaluated beforehand, it is recommended that a new cycle of chemotherapy is not started until it is resolved or has regression to grade 2 or less, the cycle may be postponed from one to two weeks for full recovery or until it is not limiting for continuity with the treatment. If the expected recovery is not possible, suspension of treatment should be considered. Final considerations: The pharmaceutical evaluation is essential in the identification of toxicities, since he has elementary knowledge of the adverse effects and toxicities of drugs, thus being able to assist the medical team in the decisions of complementary therapy. Keywords: 5-fluoruracil, cancer colorectal, capecitabine, CTCAE, irinotecan, metastasis, toxicity. Expandir Resumo Acessar Texto Completo