Resumo: Introduction: Pharmaceutical Care proposes that the pharmaceutical professional acts by identifying, intervening and preventing the Problems Related to Medicines (PRM), through actions that promote rational use. Review: Systematic literature of the integrative type of relevant evidence-based studies, which were published between the years 2007 and 2020 in the Google Scholar, Lilacs, PubMed and SciElo databases, in English, Spanish and Portuguese. Discussion: The literature review allows addressing the main barriers of Pharmaceutical Care in UBS, evaluating the participation of the pharmacist and highlighting its importance in promoting access and rational use of medicines, with approaches that highlight the difficulties of insertion. Final considerations: Despite the barriers faced by the pharmaceutical professional, it is extremely important to act in front of the health team, since the pharmacist has scientific technical knowledge with regard to Pharmaceutical Care, thus promoting effective and quality care. However, it is important that the professional is inserted to carry out the actions inherent to their training, aiming at success in the users' pharmacotherapy. Keywords: pharmaceutical care, pharmacotherapeutics, PRM, rational use of medicines. Expandir Resumo Acessar Texto Completo

Resumo: Introduction: To present the therapeutic effects of warfarin in the treatment of arterial thrombosis and its medicinal and dietary changes. Review: This is a descriptive study, systematic literature review, through the search of electronic databases such as PubMed, Google Scholar, SciELO. The search was guided by indexing descriptors such as pharmacotherapy, arterial thrombosis, warfarin, thrombotic events, using databases from the Virtual Health Library. Discussion: The present study was carried out through a literature review to demonstrate the effect of warfarin in the treatment of arterial thrombosis, as a possible alternative anticoagulant therapy in comparison to the new oral anticoagulant drugs. Discussion: More than 200 drug and food interactions have been identified with the use of warfarin, which may enhance or decrease its effect. Thus, warfarin proved to be effective, with the advantages of being a drug that is easy to administer, low cost, besides allowing the control and monitoring of dosage according to the needs of each patient, however, the disadvantages of using warfarin about the new anticoagulants they are: Unpredictable and individual pharmacokinetics, dietary restrictions, need for frequent monitoring of INR, slow onset and compensation, long half-life. Final Considerations: As shown in this study, warfarin is an effective anticoagulant drug and more prescribed in clinical practice. arterial thrombosis pharmacotherapy Keywords: bioavailability, bioequivalence, generic drugs. Expandir Resumo Acessar Texto Completo