Início Biomarcadores Troponina I e T no Diagnóstico do Infarto Agudo do Miocárdio
percentil 99
Biomarcadores Troponina I e T no Diagnóstico do Infarto Agudo do Miocárdio
Resumo:
Troponins (cTn), also known as cardiac biomarkers, are proteins that regulate muscle contraction, both in skeletal and cardiac muscle. Its molecule is composed of three subunits: troponin I (cTnI), troponin T (cTnT), and troponin C (cTnC). cTn plays a key role in the diagnosis of acute myocardial infarction (AMI) due to its high cardio-specificity and its prolonged release into the bloodstream after a cardiac injury. They can be identified through specific tests. The elevation of cTn levels indicates the presence of an infarction, with the release starting a few hours after the onset of symptoms. Blood tests are used for the detection and interpretation of cTn levels, and the diagnosis of AMI is established when the concentration exceeds a predefined threshold. However, in addition to indicating AMI, cTn can be detected in other pathological conditions, both cardiac and non-cardiac, such as: high blood pressure in the lungs, pulmonary embolism, congestive heart failure, inflammation of the cardiac muscles, and chronic kidney disease. This fact should be taken into consideration when analyzing the results, to avoid false positives. In summary, the determination of cTn levels plays an important role in the clinical evaluation of patients with suspected AMI, allowing for a precise and rapid diagnosis, with the aim of increasing population survival.
Keywords: Cardiac biomarkers, acute myocardial infarction, troponin I and T, troponin assays, 99th percentile.
Expandir Resumo
Acessar Texto Completo